종양미세환경내 Porphyromonas gingivalis가 구강암세포내 유전자 발현에 미치는 영향
Effect of Porphyromonas gingivalis in Tumor Microenvironment on Genetic Changes of Oral Cancer Cells
위신욱, 우복희, 이지혜, 박봉수, 박혜련,
소속 상세정보
위신욱 ( Wi Sin-Wook ) - 부산대학교 치의학전문대학원 구강병리학교실
우복희 ( Woo Vok-Hee ) - 부산대학교 치의학전문대학원 구강병리학교실
이지혜 ( Lee Ji-Hye ) - 부산대학교 치의학전문대학원 구경병리학교실
박봉수 ( Park Bong-Soo ) - 부산대학교 치의학전문대학원 구강해부학교실
박혜련 ( Park Hae-Ryoun ) - 부산대학교 치의학전문대학원 구강병리학교실
KMID : 0829220160400060871
Abstract
Recently, the importance of inflammation in carcinogenesis has been recognized and studied extensively. As a result, a clear correlation between inflammation and carcinogenesis has been well established in some types of cancers. Despite a high prevalence of chronic periodontitis, one of the most common inflammatory diseases in the general population, there are only a few reports on the role of chronic periodontitis in oral cancer progression. In this study, we aimed to investigate genetic changes in oral cancer cells induced by repetitive Porphryomonas gingivalis infections to mimic chronic periodontitis in a clinical setting. Cells of oral squamous cell carcinoma (OSCC), the most common type of oral cancer, and P. gingivalis 381 were used for the present study. ID1 and ID3 were mRNAs of higher expression in the P. gingivalis-infected group compared to the uninfected control. These mRNAs have been regarded as important modulators participating in cancer progression. Future studies will provide an insight into the roles of the molecules we identified in oral cancer progression. Outcomes from these studies will also shed light on the significance of chronic periodontitis induced by bacterial pathogen, such as P. gingivalis, in progression of oral cancer and relevant molecular mechanisms underlying altered cancer cell behaviors.
키워드
Porphyromonas gingivalis; Genetic changes; Oral cancer cells
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